<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:85909f56-ab42-477d-96a1-528c514b5c3d,g:6a735e25-42b3-45ec-8f47-f123d75464c9-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CoverPage" xlink:type="simple" xlink:href="isrg-20201231.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_750c7f5e-f000-4145-92f2-3fd9cfaee7f7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:to="loc_us-gaap_AssetsCurrent_750c7f5e-f000-4145-92f2-3fd9cfaee7f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ad6ff63e-93e1-4440-bca9-2892c9f3b729" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_ad6ff63e-93e1-4440-bca9-2892c9f3b729" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_fc00e697-a691-413e-a21d-55a699b4ac50" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_fc00e697-a691-413e-a21d-55a699b4ac50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_5c7b03cf-350b-4684-b606-d4665a08032e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_5c7b03cf-350b-4684-b606-d4665a08032e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_IntangibleAndOtherAssets_9a760ca4-1c29-445e-8749-54d2ee28cafe" xlink:href="isrg-20201231.xsd#isrg_IntangibleAndOtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:to="loc_isrg_IntangibleAndOtherAssets_9a760ca4-1c29-445e-8749-54d2ee28cafe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_345d621a-1122-4dc0-b5fa-4f56d89a8322" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6a252ff2-6652-4652-af5a-d27d4c4cb95a" xlink:to="loc_us-gaap_Goodwill_345d621a-1122-4dc0-b5fa-4f56d89a8322" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_8445bf62-6531-4ce0-bd1b-5ec592f13c8b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f6223d0f-7d99-417c-a4ed-0110df8ee371" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_8445bf62-6531-4ce0-bd1b-5ec592f13c8b" xlink:to="loc_us-gaap_Liabilities_f6223d0f-7d99-417c-a4ed-0110df8ee371" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_c792bbf4-de12-4029-ab4a-bf7f4f7c74ef" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_8445bf62-6531-4ce0-bd1b-5ec592f13c8b" xlink:to="loc_us-gaap_CommitmentsAndContingencies_c792bbf4-de12-4029-ab4a-bf7f4f7c74ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_2b7cf03a-b46c-43a4-b850-f445346f8305" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_8445bf62-6531-4ce0-bd1b-5ec592f13c8b" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_2b7cf03a-b46c-43a4-b850-f445346f8305" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_ac3caf89-ca85-424a-8488-cac110fe9706" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_85e93c3e-d2d2-4b8c-b784-759e1d607bb1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_ac3caf89-ca85-424a-8488-cac110fe9706" xlink:to="loc_us-gaap_LiabilitiesCurrent_85e93c3e-d2d2-4b8c-b784-759e1d607bb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_eadabe44-f9f6-413a-a7bc-8c4dcbd2bccc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_ac3caf89-ca85-424a-8488-cac110fe9706" xlink:to="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_eadabe44-f9f6-413a-a7bc-8c4dcbd2bccc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_4f3631d2-39cb-4564-be43-6d34042b36aa" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e73b9bc3-aa2b-4c8f-ae41-204e40a7f07b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4f3631d2-39cb-4564-be43-6d34042b36aa" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e73b9bc3-aa2b-4c8f-ae41-204e40a7f07b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_2e998af9-2c74-44f7-afdc-eb73357f18af" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4f3631d2-39cb-4564-be43-6d34042b36aa" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_2e998af9-2c74-44f7-afdc-eb73357f18af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_173cf01b-038c-4ae5-a134-e43e605c2de0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4f3631d2-39cb-4564-be43-6d34042b36aa" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_173cf01b-038c-4ae5-a134-e43e605c2de0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_91219fb8-8b81-4866-b992-580f8896863a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4f3631d2-39cb-4564-be43-6d34042b36aa" xlink:to="loc_us-gaap_InventoryNet_91219fb8-8b81-4866-b992-580f8896863a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6d4cd8bc-2848-42c4-90da-24dd93892e50" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_4f3631d2-39cb-4564-be43-6d34042b36aa" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_6d4cd8bc-2848-42c4-90da-24dd93892e50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1cd48657-a34e-43c2-8961-bac377a86c10" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_148dd636-4d32-4428-b82e-178cf8024f55" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1cd48657-a34e-43c2-8961-bac377a86c10" xlink:to="loc_us-gaap_StockholdersEquity_148dd636-4d32-4428-b82e-178cf8024f55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_b1dd694b-ac19-44a6-a7d4-2dfc632cf45b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_1cd48657-a34e-43c2-8961-bac377a86c10" xlink:to="loc_us-gaap_MinorityInterest_b1dd694b-ac19-44a6-a7d4-2dfc632cf45b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_514a789f-4b9d-492b-975b-a6fdc0ed21f6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_4946134d-7470-4bb0-8d80-8c659aa85cd6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_514a789f-4b9d-492b-975b-a6fdc0ed21f6" xlink:to="loc_us-gaap_PreferredStockValue_4946134d-7470-4bb0-8d80-8c659aa85cd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_d17fa7c5-3080-40e4-81d6-d521c90a2ec8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_514a789f-4b9d-492b-975b-a6fdc0ed21f6" xlink:to="loc_us-gaap_CommonStockValue_d17fa7c5-3080-40e4-81d6-d521c90a2ec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_e4f78abf-4cd0-4c61-be39-c34d27214445" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_514a789f-4b9d-492b-975b-a6fdc0ed21f6" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_e4f78abf-4cd0-4c61-be39-c34d27214445" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_45a6c625-3c5d-4fc3-b706-784991f78ae7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_514a789f-4b9d-492b-975b-a6fdc0ed21f6" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_45a6c625-3c5d-4fc3-b706-784991f78ae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_70140fba-2f4b-4573-8c9b-7eeaea90be0c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_514a789f-4b9d-492b-975b-a6fdc0ed21f6" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_70140fba-2f4b-4573-8c9b-7eeaea90be0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_00a0aa5b-8ade-4291-9cc9-b7b4043f97d3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_c6223351-0dea-49ce-bac3-d5cd4148e32e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_00a0aa5b-8ade-4291-9cc9-b7b4043f97d3" xlink:to="loc_us-gaap_AccountsPayableCurrent_c6223351-0dea-49ce-bac3-d5cd4148e32e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_ee5fe150-e144-462c-996b-14346da4f862" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_00a0aa5b-8ade-4291-9cc9-b7b4043f97d3" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_ee5fe150-e144-462c-996b-14346da4f862" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueCurrent_f2c6e6ee-58fc-4f4a-823c-01590a2d62d0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredRevenueCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_00a0aa5b-8ade-4291-9cc9-b7b4043f97d3" xlink:to="loc_us-gaap_DeferredRevenueCurrent_f2c6e6ee-58fc-4f4a-823c-01590a2d62d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_854de237-d2fe-4c64-8422-a36faa7d2d57" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_00a0aa5b-8ade-4291-9cc9-b7b4043f97d3" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_854de237-d2fe-4c64-8422-a36faa7d2d57" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfIncome" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedStatementsOfIncome"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6d3dd86f-7c61-4509-bc29-8dd3399c9ed1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_ae18be44-0fe3-40f0-8c2a-4a7a07e5ae8e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_6d3dd86f-7c61-4509-bc29-8dd3399c9ed1" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_ae18be44-0fe3-40f0-8c2a-4a7a07e5ae8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_ba886b08-463d-47b3-931d-49505a7eca05" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_6d3dd86f-7c61-4509-bc29-8dd3399c9ed1" xlink:to="loc_us-gaap_ProfitLoss_ba886b08-463d-47b3-931d-49505a7eca05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_bfda0157-67f5-47ff-91ef-b47630feee20" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_1b52c32b-7581-43b5-a854-da9fd0644d96" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_bfda0157-67f5-47ff-91ef-b47630feee20" xlink:to="loc_us-gaap_GrossProfit_1b52c32b-7581-43b5-a854-da9fd0644d96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_a31a29f1-a19b-4668-b874-caa88868210c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_bfda0157-67f5-47ff-91ef-b47630feee20" xlink:to="loc_us-gaap_OperatingExpenses_a31a29f1-a19b-4668-b874-caa88868210c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_1acd082b-b56e-4afc-9832-366ff3bd6704" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ab61795f-7139-4fc1-860f-dacb4b110aaf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_1acd082b-b56e-4afc-9832-366ff3bd6704" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_ab61795f-7139-4fc1-860f-dacb4b110aaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_d4fdc3a4-dfd0-4430-adb0-e74f8f68006e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_1acd082b-b56e-4afc-9832-366ff3bd6704" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_d4fdc3a4-dfd0-4430-adb0-e74f8f68006e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_2c2837b6-9e54-462c-8ec6-c589d2abf4e0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_248023d0-3d9a-427a-b645-58bd03185d5a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_2c2837b6-9e54-462c-8ec6-c589d2abf4e0" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_248023d0-3d9a-427a-b645-58bd03185d5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8fc49ec1-db51-48c4-abf7-301ded717176" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_2c2837b6-9e54-462c-8ec6-c589d2abf4e0" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8fc49ec1-db51-48c4-abf7-301ded717176" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_3fd0e3f7-ba2c-46e3-8609-32bdbed3f198" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_466f9c51-b045-4e99-a5c7-c48df3d452c4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_3fd0e3f7-ba2c-46e3-8609-32bdbed3f198" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_466f9c51-b045-4e99-a5c7-c48df3d452c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_3603f116-cec3-4b6d-9331-1bf3e134c04a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_3fd0e3f7-ba2c-46e3-8609-32bdbed3f198" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_3603f116-cec3-4b6d-9331-1bf3e134c04a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_9a43c375-bb20-4e13-97ad-f86dcf8c9c64" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e3bffa06-f3ba-4f9f-a95d-5773df39a6f8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_9a43c375-bb20-4e13-97ad-f86dcf8c9c64" xlink:to="loc_us-gaap_OperatingIncomeLoss_e3bffa06-f3ba-4f9f-a95d-5773df39a6f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_95ea3732-03fc-4b05-bfa2-1907d2c254c0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_9a43c375-bb20-4e13-97ad-f86dcf8c9c64" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_95ea3732-03fc-4b05-bfa2-1907d2c254c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedStatementsOfComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_6beb24a5-6869-4840-9f55-569cb9002d34" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_366f5d6a-919a-4140-acb5-f8bd1e077a80" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_6beb24a5-6869-4840-9f55-569cb9002d34" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_366f5d6a-919a-4140-acb5-f8bd1e077a80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_f238ed9f-416b-4b4d-a34e-edb8167f046e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_6beb24a5-6869-4840-9f55-569cb9002d34" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_f238ed9f-416b-4b4d-a34e-edb8167f046e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_fd02805c-cb2c-4860-a528-fc950b02a385" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax_791da27b-6c74-4d35-90da-0f291027d785" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_fd02805c-cb2c-4860-a528-fc950b02a385" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax_791da27b-6c74-4d35-90da-0f291027d785" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_4cc212a4-76e1-4da3-be8d-f68b6ffceb61" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_fd02805c-cb2c-4860-a528-fc950b02a385" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_4cc212a4-76e1-4da3-be8d-f68b6ffceb61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_094f8c83-b606-4e03-a1e9-3cfcdf744e77" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_139aa4b2-00f8-47ec-babc-5eba5183c4f2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_094f8c83-b606-4e03-a1e9-3cfcdf744e77" xlink:to="loc_us-gaap_NetIncomeLoss_139aa4b2-00f8-47ec-babc-5eba5183c4f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51ec343c-bb6b-42c7-94d7-b50cd22c7a74" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_094f8c83-b606-4e03-a1e9-3cfcdf744e77" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51ec343c-bb6b-42c7-94d7-b50cd22c7a74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_b13bc2e1-d7cb-48e9-881b-7a9fcb324078" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_0818f3cd-a6d0-43c2-b184-d9ee8c0e2d1a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_b13bc2e1-d7cb-48e9-881b-7a9fcb324078" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_0818f3cd-a6d0-43c2-b184-d9ee8c0e2d1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossNetOfTax_043ce7e5-ef07-4688-a750-ff92a7f63e36" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_b13bc2e1-d7cb-48e9-881b-7a9fcb324078" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossNetOfTax_043ce7e5-ef07-4688-a750-ff92a7f63e36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d9515d91-4ba4-4a52-93a8-4c4e8d607215" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_9074a092-c489-4b83-a0b5-d0e90ea34b90" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d9515d91-4ba4-4a52-93a8-4c4e8d607215" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_9074a092-c489-4b83-a0b5-d0e90ea34b90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_27e1b0b7-3823-4cbc-96cd-608241b577db" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d9515d91-4ba4-4a52-93a8-4c4e8d607215" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_27e1b0b7-3823-4cbc-96cd-608241b577db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_42be40a7-5347-4ade-b967-5dc93e3f73eb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d9515d91-4ba4-4a52-93a8-4c4e8d607215" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_42be40a7-5347-4ade-b967-5dc93e3f73eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_8f09e4dd-5370-4887-ae0c-5b7df0715c4b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_d9515d91-4ba4-4a52-93a8-4c4e8d607215" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_8f09e4dd-5370-4887-ae0c-5b7df0715c4b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedStatementsOfStockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedStatementsOfCashFlows"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_05cbdf13-985d-4188-981d-4cad6f6fa54e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_61b67968-2431-4906-839e-bd7dbc42f7dd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_05cbdf13-985d-4188-981d-4cad6f6fa54e" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_61b67968-2431-4906-839e-bd7dbc42f7dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_6a432558-b3dc-4ba5-88cb-a5f22e48f2d1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_05cbdf13-985d-4188-981d-4cad6f6fa54e" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_6a432558-b3dc-4ba5-88cb-a5f22e48f2d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_c67f0ace-8e1a-4daf-af0d-23ea219cb551" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_05cbdf13-985d-4188-981d-4cad6f6fa54e" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_c67f0ace-8e1a-4daf-af0d-23ea219cb551" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_cdd8252f-029d-4bb8-a70d-cdc84720cec8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_05cbdf13-985d-4188-981d-4cad6f6fa54e" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_cdd8252f-029d-4bb8-a70d-cdc84720cec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_5dec7954-b5e0-4e98-87d3-007a0a8da8b5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_05cbdf13-985d-4188-981d-4cad6f6fa54e" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_5dec7954-b5e0-4e98-87d3-007a0a8da8b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0e04216f-2dfb-40c2-a309-c74958a9debb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e5cea20e-6d71-413d-85ba-e2faf9a682b5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0e04216f-2dfb-40c2-a309-c74958a9debb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e5cea20e-6d71-413d-85ba-e2faf9a682b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4beada36-33a1-4761-991f-5e2a32447aea" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0e04216f-2dfb-40c2-a309-c74958a9debb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4beada36-33a1-4761-991f-5e2a32447aea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_de301dcd-31ed-42c0-8853-3e609c8c2c30" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0e04216f-2dfb-40c2-a309-c74958a9debb" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_de301dcd-31ed-42c0-8853-3e609c8c2c30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_7191a8a1-d412-4c6d-b106-e7741c8f1abb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0e04216f-2dfb-40c2-a309-c74958a9debb" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_7191a8a1-d412-4c6d-b106-e7741c8f1abb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c2c0a18-d506-48fa-8a5d-ef015303d116" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_d609f639-8bbf-44b8-8451-81f003a6e1b8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c2c0a18-d506-48fa-8a5d-ef015303d116" xlink:to="loc_us-gaap_ProceedsFromStockPlans_d609f639-8bbf-44b8-8451-81f003a6e1b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_87b04314-9ffc-41ca-92ac-90cc8384f9b9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c2c0a18-d506-48fa-8a5d-ef015303d116" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_87b04314-9ffc-41ca-92ac-90cc8384f9b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_0b61521f-50ec-40ee-881a-411a9588936b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c2c0a18-d506-48fa-8a5d-ef015303d116" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_0b61521f-50ec-40ee-881a-411a9588936b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMinorityShareholders_99b87c94-d677-4bfc-912e-7a30b943943a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromMinorityShareholders"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c2c0a18-d506-48fa-8a5d-ef015303d116" xlink:to="loc_us-gaap_ProceedsFromMinorityShareholders_99b87c94-d677-4bfc-912e-7a30b943943a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_39f7887b-dc98-4e28-afa8-c33a9286e2e0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_4c2c0a18-d506-48fa-8a5d-ef015303d116" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_39f7887b-dc98-4e28-afa8-c33a9286e2e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_5b447fce-05ec-4008-b748-5be5f41a56d0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_ProfitLoss_5b447fce-05ec-4008-b748-5be5f41a56d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_DepreciationandGainLossonDispositionofPropertyPlantEquipment_a94013a1-55ce-46d4-87e7-7a77e4f3846e" xlink:href="isrg-20201231.xsd#isrg_DepreciationandGainLossonDispositionofPropertyPlantEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_isrg_DepreciationandGainLossonDispositionofPropertyPlantEquipment_a94013a1-55ce-46d4-87e7-7a77e4f3846e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_41c1577d-17db-444e-994d-7475044e9add" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_41c1577d-17db-444e-994d-7475044e9add" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_3b201ede-865c-46d0-9365-eb234226cf9f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_3b201ede-865c-46d0-9365-eb234226cf9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_36b7f295-3648-43c0-b7cb-fd8b14a36814" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_36b7f295-3648-43c0-b7cb-fd8b14a36814" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_74b56ab7-5329-4d93-8811-24c3b33b1c4a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_ShareBasedCompensation_74b56ab7-5329-4d93-8811-24c3b33b1c4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedContractCostAmortization_716a4358-de16-4b9b-9efc-cc449981926c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CapitalizedContractCostAmortization"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_CapitalizedContractCostAmortization_716a4358-de16-4b9b-9efc-cc449981926c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_eb89eaa0-5075-4590-a077-f96b91e3250d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_eb89eaa0-5075-4590-a077-f96b91e3250d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_996f5434-928b-4fd4-9305-f0d9379b86a9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_996f5434-928b-4fd4-9305-f0d9379b86a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_3dcef795-f0ae-48d4-b899-63d4c1c36850" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_3dcef795-f0ae-48d4-b899-63d4c1c36850" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_0cd4f751-9eab-4f13-a7c2-7068e1ff9978" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_0cd4f751-9eab-4f13-a7c2-7068e1ff9978" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_6f14a6e2-e1bf-453d-851b-d0b8a2449b2e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_6f14a6e2-e1bf-453d-851b-d0b8a2449b2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_dc0bc613-3e1b-40f6-9332-c9c371c03286" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_dc0bc613-3e1b-40f6-9332-c9c371c03286" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_0aa465e6-7207-4737-b399-cb1a6bfcf4a4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5423f3d4-2e9b-4817-92bf-380b26acf862" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_0aa465e6-7207-4737-b399-cb1a6bfcf4a4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/DescriptionoftheBusiness" xlink:type="simple" xlink:href="isrg-20201231.xsd#DescriptionoftheBusiness"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/DescriptionoftheBusiness" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="simple" xlink:href="isrg-20201231.xsd#SummaryOfSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="isrg-20201231.xsd#SummaryOfSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#SummaryOfSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#SummaryOfSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesEstimatedUsefulLivesOfAssetsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#SummaryOfSignificantAccountingPoliciesEstimatedUsefulLivesOfAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesEstimatedUsefulLivesOfAssetsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesAmortizedCostbyCreditQualityDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#SummaryOfSignificantAccountingPoliciesAmortizedCostbyCreditQualityDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SummaryOfSignificantAccountingPoliciesAmortizedCostbyCreditQualityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear_b637da57-e612-4543-9a37-1d7254959680" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear_b637da57-e612-4543-9a37-1d7254959680" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear_054c9b1e-447f-4737-af40-ec0477a7ee44" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear_054c9b1e-447f-4737-af40-ec0477a7ee44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear_26c90020-8ebb-4f53-b04f-d49c498f2e35" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear_26c90020-8ebb-4f53-b04f-d49c498f2e35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear_adcb8e95-147f-440e-9ed6-6884c059fa59" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear_adcb8e95-147f-440e-9ed6-6884c059fa59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear_6c0f107a-b6b2-43b1-a554-eba2f2d040d1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear_6c0f107a-b6b2-43b1-a554-eba2f2d040d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_db7f34fb-62bb-4019-9b36-046fc6b3cdc2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_0a8e0d43-8859-4af5-9681-8cd8eadb8d0c" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_db7f34fb-62bb-4019-9b36-046fc6b3cdc2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstruments" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstruments"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstruments" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsSummaryOfCashAndAvailableForSaleSecuritiesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsSummaryOfCashAndAvailableForSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsSummaryOfCashAndAvailableForSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_8c878cf3-7b0d-4589-92e6-149722a1dd0f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_64a2aec0-9afb-4fe1-8714-0efccee97f74" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_8c878cf3-7b0d-4589-92e6-149722a1dd0f" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_64a2aec0-9afb-4fe1-8714-0efccee97f74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_056e54fc-59dd-43cc-98a9-7d1ecb1ed1fd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_8c878cf3-7b0d-4589-92e6-149722a1dd0f" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_056e54fc-59dd-43cc-98a9-7d1ecb1ed1fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ed890796-c665-48df-ae0a-b3befb3524c4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_8c878cf3-7b0d-4589-92e6-149722a1dd0f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ed890796-c665-48df-ae0a-b3befb3524c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_b190741a-75dd-4863-8a7b-bcb292b724af" xlink:href="isrg-20201231.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_958380de-04e4-4134-8a4f-c020421a01fe" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_b190741a-75dd-4863-8a7b-bcb292b724af" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_958380de-04e4-4134-8a4f-c020421a01fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_654566e7-77ab-40f2-85cb-f1c65f0dd45e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_b190741a-75dd-4863-8a7b-bcb292b724af" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_654566e7-77ab-40f2-85cb-f1c65f0dd45e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_62a3c5d4-ba7a-4750-8fe6-832e2544964e" xlink:href="isrg-20201231.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8fbe0d0b-ee3f-4a38-9a8c-5fcf6a1aa638" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_62a3c5d4-ba7a-4750-8fe6-832e2544964e" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_8fbe0d0b-ee3f-4a38-9a8c-5fcf6a1aa638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_9c275576-d655-4cdf-8d15-cc932b66c61b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_62a3c5d4-ba7a-4750-8fe6-832e2544964e" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_9c275576-d655-4cdf-8d15-cc932b66c61b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsSummaryOfContractualMaturitiesOfCashEquivalentsAndAvailableForSaleInvestmentsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsSummaryOfContractualMaturitiesOfCashEquivalentsAndAvailableForSaleInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsSummaryOfContractualMaturitiesOfCashEquivalentsAndAvailableForSaleInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b3a42850-aa73-4f81-9a4c-b15d683045a8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_8d141c06-8ff7-4197-9e5a-bdff8c9810be" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b3a42850-aa73-4f81-9a4c-b15d683045a8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_8d141c06-8ff7-4197-9e5a-bdff8c9810be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_e4369757-33e4-4702-808e-f324454bb812" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b3a42850-aa73-4f81-9a4c-b15d683045a8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_e4369757-33e4-4702-808e-f324454bb812" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_85273e02-7186-4e96-bafc-ab45609d9c2a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_e0febb68-b41e-4020-93e8-3ad6b81babe5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_85273e02-7186-4e96-bafc-ab45609d9c2a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_e0febb68-b41e-4020-93e8-3ad6b81babe5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_1f863057-7e4a-4523-8987-5b32baf63e61" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_85273e02-7186-4e96-bafc-ab45609d9c2a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_1f863057-7e4a-4523-8987-5b32baf63e61" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsScheduleOfAvailableForSaleInvestmentsWithUnrealizedLossesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsScheduleOfAvailableForSaleInvestmentsWithUnrealizedLossesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsScheduleOfAvailableForSaleInvestmentsWithUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_ebe88f9f-5566-4e91-8db0-5d6f86da0a46" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_ff74c88c-3d3f-4e56-932d-c1158c270232" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_ebe88f9f-5566-4e91-8db0-5d6f86da0a46" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_ff74c88c-3d3f-4e56-932d-c1158c270232" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_0b0ceaee-adfa-41f3-b79d-d67555040161" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_ebe88f9f-5566-4e91-8db0-5d6f86da0a46" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_0b0ceaee-adfa-41f3-b79d-d67555040161" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_8e8f8906-9b7c-4815-89c4-7d1930884732" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_99aa21bc-01c9-44d3-b13b-41d634e5f8e7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_8e8f8906-9b7c-4815-89c4-7d1930884732" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_99aa21bc-01c9-44d3-b13b-41d634e5f8e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_869e132d-171b-4d7c-9bea-ae52f56d7c09" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_8e8f8906-9b7c-4815-89c4-7d1930884732" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_869e132d-171b-4d7c-9bea-ae52f56d7c09" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsSummaryofEquityInvestmentActivityDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsSummaryofEquityInvestmentActivityDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsSummaryofEquityInvestmentActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsDerivativeInstrumentsUsedtoHedgeagainstBalanceSheetForeignCurrencyExposuresDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsDerivativeInstrumentsUsedtoHedgeagainstBalanceSheetForeignCurrencyExposuresDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsDerivativeInstrumentsUsedtoHedgeagainstBalanceSheetForeignCurrencyExposuresDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FinancialInstrumentsGrossNotionalAmountsforOutstandingDerivativesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#FinancialInstrumentsGrossNotionalAmountsforOutstandingDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FinancialInstrumentsGrossNotionalAmountsforOutstandingDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsInventoryDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_7c0a467a-2378-46ff-8706-cbace40e4bf0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_ee4ebd8c-3a90-442c-a41c-276876d6c961" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_7c0a467a-2378-46ff-8706-cbace40e4bf0" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_ee4ebd8c-3a90-442c-a41c-276876d6c961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_d3496c60-5c20-482b-ab78-2abab2fb248e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_7c0a467a-2378-46ff-8706-cbace40e4bf0" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_d3496c60-5c20-482b-ab78-2abab2fb248e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_40962cc7-999d-4066-b8fb-d4f23e3c7bca" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_7c0a467a-2378-46ff-8706-cbace40e4bf0" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_40962cc7-999d-4066-b8fb-d4f23e3c7bca" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsPropertyPlantandEquipmentNetDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsPropertyPlantandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsPropertyPlantandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_70ad5655-2fe4-4276-a9e9-fe9528633ba8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_0f9d835b-e3e7-44c8-a502-79ece9099a84" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_70ad5655-2fe4-4276-a9e9-fe9528633ba8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_0f9d835b-e3e7-44c8-a502-79ece9099a84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e59636f9-5fc9-4ca6-93e2-4b05a3bdb1c3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_70ad5655-2fe4-4276-a9e9-fe9528633ba8" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e59636f9-5fc9-4ca6-93e2-4b05a3bdb1c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Land_59122190-21e6-42e0-8c03-cf2e65ae6f01" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Land"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_us-gaap_Land_59122190-21e6-42e0-8c03-cf2e65ae6f01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_98e35c83-f68e-4483-98da-615d0e521fdf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BuildingsAndImprovementsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_98e35c83-f68e-4483-98da-615d0e521fdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_ef796df3-517a-42cd-9b96-c73b118142d7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MachineryAndEquipmentGross"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_ef796df3-517a-42cd-9b96-c73b118142d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseGross_5ebb79cc-1cce-4a26-8d44-1eaa6a1aa45b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertySubjectToOrAvailableForOperatingLeaseGross"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_us-gaap_PropertySubjectToOrAvailableForOperatingLeaseGross_5ebb79cc-1cce-4a26-8d44-1eaa6a1aa45b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_ComputerAndOfficeEquipment_bb3cf5f3-dc3a-4ada-9b84-a678558f1f16" xlink:href="isrg-20201231.xsd#isrg_ComputerAndOfficeEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_isrg_ComputerAndOfficeEquipment_bb3cf5f3-dc3a-4ada-9b84-a678558f1f16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareGross_1da13471-6dbb-448f-8b16-f726f1f7201a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CapitalizedComputerSoftwareGross"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareGross_1da13471-6dbb-448f-8b16-f726f1f7201a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_1892141c-6645-4050-88d6-97d5e04afc01" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_a50265a9-e314-49e9-8b07-f28e19af91a0" xlink:to="loc_us-gaap_ConstructionInProgressGross_1892141c-6645-4050-88d6-97d5e04afc01" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsOtherAccruedLiabilitiesShortTermDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsOtherAccruedLiabilitiesShortTermDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsOtherAccruedLiabilitiesShortTermDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_46ce818f-6327-4eca-827b-d69f8c3b074c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_1c5a94a0-b708-450e-9518-252da2bae6c5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_46ce818f-6327-4eca-827b-d69f8c3b074c" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_1c5a94a0-b708-450e-9518-252da2bae6c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_dd8971ca-5b1b-4c37-b3cc-c56c0961c0ad" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_46ce818f-6327-4eca-827b-d69f8c3b074c" xlink:to="loc_us-gaap_LitigationReserveCurrent_dd8971ca-5b1b-4c37-b3cc-c56c0961c0ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_3dc4d7cc-fca0-4d85-9433-a7d23d16ed2f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_46ce818f-6327-4eca-827b-d69f8c3b074c" xlink:to="loc_us-gaap_TaxesPayableCurrent_3dc4d7cc-fca0-4d85-9433-a7d23d16ed2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_DeferredPurchaseConsiderationPaymentsCurrent_a3cf5fba-54b5-40b9-880e-695952f5669f" xlink:href="isrg-20201231.xsd#isrg_DeferredPurchaseConsiderationPaymentsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_46ce818f-6327-4eca-827b-d69f8c3b074c" xlink:to="loc_isrg_DeferredPurchaseConsiderationPaymentsCurrent_a3cf5fba-54b5-40b9-880e-695952f5669f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_32527bb0-59fb-460c-998f-23287cfc0c1e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_46ce818f-6327-4eca-827b-d69f8c3b074c" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_32527bb0-59fb-460c-998f-23287cfc0c1e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsOtherLongTermLiabilitiesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsOtherLongTermLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsOtherLongTermLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_bc06056c-1e00-4108-bc25-9d43c562b71d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_a3bdf840-52ce-4c02-a600-3c12ca01f23e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_bc06056c-1e00-4108-bc25-9d43c562b71d" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_a3bdf840-52ce-4c02-a600-3c12ca01f23e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_8dab3a40-f2ec-4dc4-b293-ca433b3b53e1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredRevenueNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_bc06056c-1e00-4108-bc25-9d43c562b71d" xlink:to="loc_us-gaap_DeferredRevenueNoncurrent_8dab3a40-f2ec-4dc4-b293-ca433b3b53e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_a79c2d03-e7ae-4412-8661-44db7ab61eaf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAccruedLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_bc06056c-1e00-4108-bc25-9d43c562b71d" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_a79c2d03-e7ae-4412-8661-44db7ab61eaf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsSupplementalCashFlowInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsSupplementalCashFlowInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsSupplementalCashFlowInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsDetailsPrepaidsandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ConsolidatedFinancialStatementDetailsDetailsPrepaidsandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ConsolidatedFinancialStatementDetailsDetailsPrepaidsandOtherCurrentAssetsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/Revenue" xlink:type="simple" xlink:href="isrg-20201231.xsd#Revenue"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/Revenue" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueRevenueDisaggregatedbyTypesandGeographyDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueRevenueDisaggregatedbyTypesandGeographyDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueRevenueDisaggregatedbyTypesandGeographyDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueRemainingPerformanceObligationsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueRemainingPerformanceObligationsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueRemainingPerformanceObligationsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueRemainingPerformanceObligationsDetails_1" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueRemainingPerformanceObligationsDetails_1"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueRemainingPerformanceObligationsDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueSummaryofContractAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueSummaryofContractAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueSummaryofContractAssetsandLiabilitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/RevenueSalestypeandOperatingLeaseRevenueDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#RevenueSalestypeandOperatingLeaseRevenueDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/RevenueSalestypeandOperatingLeaseRevenueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/Leases" xlink:type="simple" xlink:href="isrg-20201231.xsd#Leases"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/Leases" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesLeaseReceivablesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesLeaseReceivablesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesLeaseReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_a2c5f3f8-d4f3-4dda-bcac-bd1ee78ce9ff" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseLeaseReceivable_5c57529a-1cd5-4000-9e83-c2a8696fcca1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseLeaseReceivable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_a2c5f3f8-d4f3-4dda-bcac-bd1ee78ce9ff" xlink:to="loc_us-gaap_SalesTypeLeaseLeaseReceivable_5c57529a-1cd5-4000-9e83-c2a8696fcca1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalestypeLeaseDeferredSellingProfit_10f18f9e-5e51-49f7-a74f-77fea8a7aeda" xlink:href="isrg-20201231.xsd#isrg_SalestypeLeaseDeferredSellingProfit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_a2c5f3f8-d4f3-4dda-bcac-bd1ee78ce9ff" xlink:to="loc_isrg_SalestypeLeaseDeferredSellingProfit_10f18f9e-5e51-49f7-a74f-77fea8a7aeda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss_6e57c41d-6dea-4f9f-8358-7a9d34e7ae5c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_a2c5f3f8-d4f3-4dda-bcac-bd1ee78ce9ff" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss_6e57c41d-6dea-4f9f-8358-7a9d34e7ae5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_f8ab867c-7b05-4ea0-90d7-0d7396794132" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_fd8fae23-9f86-4bac-94b7-4f3cb28c5995" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_f8ab867c-7b05-4ea0-90d7-0d7396794132" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_fd8fae23-9f86-4bac-94b7-4f3cb28c5995" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c683680b-3c78-476f-abe8-f5431a0f9eeb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_f8ab867c-7b05-4ea0-90d7-0d7396794132" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c683680b-3c78-476f-abe8-f5431a0f9eeb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesLeaseReceivablesDetails_1" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesLeaseReceivablesDetails_1"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesLeaseReceivablesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_56c13d56-7691-4f3b-b5aa-2f1277a5246e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseLeaseReceivable_77bc6127-bc60-4d59-9b71-5eff9352696a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseLeaseReceivable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_56c13d56-7691-4f3b-b5aa-2f1277a5246e" xlink:to="loc_us-gaap_SalesTypeLeaseLeaseReceivable_77bc6127-bc60-4d59-9b71-5eff9352696a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalestypeLeaseDeferredSellingProfit_6bb26d2c-d7ef-4909-8003-62f2321dd08b" xlink:href="isrg-20201231.xsd#isrg_SalestypeLeaseDeferredSellingProfit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_56c13d56-7691-4f3b-b5aa-2f1277a5246e" xlink:to="loc_isrg_SalestypeLeaseDeferredSellingProfit_6bb26d2c-d7ef-4909-8003-62f2321dd08b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss_e3394637-dce8-4a8a-aaeb-5ef15605c56a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CapitalLeasesNetInvestmentInSalesTypeLeases_56c13d56-7691-4f3b-b5aa-2f1277a5246e" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss_e3394637-dce8-4a8a-aaeb-5ef15605c56a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths_c92a76fa-ba8c-47f4-af19-b01a8fe748b8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths_c92a76fa-ba8c-47f4-af19-b01a8fe748b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears_6e9363fd-3315-4f21-a21f-fecb57442918" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears_6e9363fd-3315-4f21-a21f-fecb57442918" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears_66dcfc5a-1b0d-4191-82d5-10fe7df19290" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears_66dcfc5a-1b0d-4191-82d5-10fe7df19290" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears_a23ba017-8b4d-451a-9b5d-2cadc779687d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears_a23ba017-8b4d-451a-9b5d-2cadc779687d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFiveYears_3624bdc5-1052-49d6-a07f-128b1c0e9fef" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFiveYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFiveYears_3624bdc5-1052-49d6-a07f-128b1c0e9fef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThereafter_f27eba89-f7df-4fff-a16f-b8ad8f1baf6a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThereafter"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_6b7337a1-3ec2-4b4f-ae20-53a591d85dbb" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThereafter_f27eba89-f7df-4fff-a16f-b8ad8f1baf6a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesMaturitiesofOperatingLeasePaymentsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesMaturitiesofOperatingLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesMaturitiesofOperatingLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_2aa0e4ab-66ce-4fc2-813c-8ed1bb8f87ad" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths_2aa0e4ab-66ce-4fc2-813c-8ed1bb8f87ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_a9b113f9-e4b5-4488-9466-2d5e0950037e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedTwoYears_a9b113f9-e4b5-4488-9466-2d5e0950037e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_a0f4df19-70bd-4d80-94ad-ddc85a2e14d4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThreeYears_a0f4df19-70bd-4d80-94ad-ddc85a2e14d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears_e7d305ae-43b2-4dff-b84d-f4d0303d9003" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFourYears_e7d305ae-43b2-4dff-b84d-f4d0303d9003" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFiveYears_8872982b-f341-42f7-8c59-377011d6f4f7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedFiveYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedFiveYears_8872982b-f341-42f7-8c59-377011d6f4f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThereafter_f73e4fa7-0d50-4ad2-98dd-ef89f7bd74c8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LessorOperatingLeasePaymentsToBeReceivedThereafter"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceived_a27bafb7-10f1-4b89-81ee-6263657a91b9" xlink:to="loc_us-gaap_LessorOperatingLeasePaymentsToBeReceivedThereafter_f73e4fa7-0d50-4ad2-98dd-ef89f7bd74c8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesSupplementalCashFlowInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesSupplementalCashFlowInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesSupplementalCashFlowInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesSupplementalBalanceSheetInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_84ce60b9-7a83-4019-abc0-5447c311567f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_58afdf44-80c4-4dc9-b230-4f3f40559b13" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_84ce60b9-7a83-4019-abc0-5447c311567f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_58afdf44-80c4-4dc9-b230-4f3f40559b13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3873bcf8-6464-43e5-9da7-ec9f0e3e54a3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_84ce60b9-7a83-4019-abc0-5447c311567f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_3873bcf8-6464-43e5-9da7-ec9f0e3e54a3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_cad8ef7b-d8d5-4902-9508-6de640fa7dd9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_cad8ef7b-d8d5-4902-9508-6de640fa7dd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8b19e09f-1e67-43e4-8940-6707afeaac7c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8b19e09f-1e67-43e4-8940-6707afeaac7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_395f6aea-a0af-433b-8d50-e807186cfcd7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_395f6aea-a0af-433b-8d50-e807186cfcd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_1efa60af-7634-4b51-8425-5012e98e8174" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_1efa60af-7634-4b51-8425-5012e98e8174" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_254c0b55-12fb-4832-acab-29ebccfe7324" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_254c0b55-12fb-4832-acab-29ebccfe7324" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_dd471c5f-ad41-40eb-b349-d172718a098d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_75bb802d-4741-458b-9776-33df9a5ad55b" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_dd471c5f-ad41-40eb-b349-d172718a098d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="isrg-20201231.xsd#LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_c253ab40-54dd-41c8-b39a-f10aa35c17cc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_f747e0ba-414e-4b61-a015-0132135d1169" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_c253ab40-54dd-41c8-b39a-f10aa35c17cc" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_f747e0ba-414e-4b61-a015-0132135d1169" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_a730b66a-979c-4c75-ab16-1a833e03636f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_c253ab40-54dd-41c8-b39a-f10aa35c17cc" xlink:to="loc_us-gaap_OperatingLeaseLiability_a730b66a-979c-4c75-ab16-1a833e03636f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IntangibleAssets" xlink:type="simple" xlink:href="isrg-20201231.xsd#IntangibleAssets"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IntangibleAssets" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#GoodwillandIntangibleAssetsTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#GoodwillandIntangibleAssetsAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsScheduleofSummaryofChangesinGoodwillDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#GoodwillandIntangibleAssetsScheduleofSummaryofChangesinGoodwillDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsScheduleofSummaryofChangesinGoodwillDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bab15f3c-9b8c-45a5-ac17-ee358daeeb1d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_85321693-0dc4-4659-93d3-55a895c9f14e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bab15f3c-9b8c-45a5-ac17-ee358daeeb1d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_85321693-0dc4-4659-93d3-55a895c9f14e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_962f26e0-fd1e-4b7c-a314-5ee72c22922b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_bab15f3c-9b8c-45a5-ac17-ee358daeeb1d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_962f26e0-fd1e-4b7c-a314-5ee72c22922b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#GoodwillandIntangibleAssetsScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GoodwillandIntangibleAssetsScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_9e1b85f9-1d93-4af3-8473-980e94e18601" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_9e1b85f9-1d93-4af3-8473-980e94e18601" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_bab011eb-5b0b-4058-80cc-654bbf8a8ba4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_bab011eb-5b0b-4058-80cc-654bbf8a8ba4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_771c603f-b06b-433a-a513-fe075a818011" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_771c603f-b06b-433a-a513-fe075a818011" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_99e5bae7-eb3a-4e63-bdd8-913b9a006288" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_99e5bae7-eb3a-4e63-bdd8-913b9a006288" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_cab64b09-82b6-42ab-8f7b-de9f1244a3b8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_cab64b09-82b6-42ab-8f7b-de9f1244a3b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_ec07ecdb-9fa7-494b-841e-874181dc4a9f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459b464e-9a58-4c75-ae7c-f5e767547f5d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_ec07ecdb-9fa7-494b-841e-874181dc4a9f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CommitmentsAndContingencies" xlink:type="simple" xlink:href="isrg-20201231.xsd#CommitmentsAndContingencies"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CommitmentsAndContingencies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CommitmentsandContingenciesAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#CommitmentsandContingenciesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CommitmentsandContingenciesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/StockholdersEquity" xlink:type="simple" xlink:href="isrg-20201231.xsd#StockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/StockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#StockholdersEquityTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/StockholdersEquityTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#StockholdersEquityAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/StockholdersEquityScheduleOfStockRepurchaseActivitiesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#StockholdersEquityScheduleOfStockRepurchaseActivitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/StockholdersEquityScheduleOfStockRepurchaseActivitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/StockholdersEquityComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#StockholdersEquityComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/StockholdersEquityComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_e36b6963-9ad4-4a84-bbcc-9bff84365729" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_ad449e6f-0e7d-47a6-9d94-79f65ac76c0d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_e36b6963-9ad4-4a84-bbcc-9bff84365729" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_ad449e6f-0e7d-47a6-9d94-79f65ac76c0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_cd77f4c0-aa35-4534-93b1-8c0c4aaaa79b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_e36b6963-9ad4-4a84-bbcc-9bff84365729" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_cd77f4c0-aa35-4534-93b1-8c0c4aaaa79b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensation" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensation"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationSummaryOfStockOptionActivityUnderAllStockPlansDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationSummaryOfStockOptionActivityUnderAllStockPlansDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationSummaryOfStockOptionActivityUnderAllStockPlansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationOutstandingandExercisableOptionsRangesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationOutstandingandExercisableOptionsRangesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationOutstandingandExercisableOptionsRangesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationSummaryofRSUActivityDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationSummaryofRSUActivityDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationSummaryofRSUActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationShareBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationShareBasedCompensationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationShareBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_3ba46ed2-fac6-4710-ba4a-bab10fb09696" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_041e4379-9cd7-44e6-9eef-39b3224ef807" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_3ba46ed2-fac6-4710-ba4a-bab10fb09696" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_041e4379-9cd7-44e6-9eef-39b3224ef807" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_a4749b1d-eae6-441f-a53c-e2797a92d159" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_3ba46ed2-fac6-4710-ba4a-bab10fb09696" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_a4749b1d-eae6-441f-a53c-e2797a92d159" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ShareBasedCompensationScheduleOfEstimatedFairValueOfOptionUsingBlackScholesOptionPricingModelWeightedAverageAssumptionsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ShareBasedCompensationScheduleOfEstimatedFairValueOfOptionUsingBlackScholesOptionPricingModelWeightedAverageAssumptionsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ShareBasedCompensationScheduleOfEstimatedFairValueOfOptionUsingBlackScholesOptionPricingModelWeightedAverageAssumptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxes" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxes"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfIncomeBeforeProvisionForIncomeTaxesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesScheduleOfIncomeBeforeProvisionForIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfIncomeBeforeProvisionForIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_16ba39e5-ea24-4c86-91a9-e511f2a738a0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_91bd51f5-6d7e-484e-b25e-7c07747bfaa9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_16ba39e5-ea24-4c86-91a9-e511f2a738a0" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_91bd51f5-6d7e-484e-b25e-7c07747bfaa9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_8ffa638a-fafb-4103-a0e5-548b9960da15" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_16ba39e5-ea24-4c86-91a9-e511f2a738a0" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_8ffa638a-fafb-4103-a0e5-548b9960da15" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfProvisionForIncomeTaxesDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesScheduleOfProvisionForIncomeTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfProvisionForIncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_c5314333-f436-4ad6-929b-b2f2e19b28fc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_aa94a20a-ee6a-444e-8acb-7c21b2928924" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c5314333-f436-4ad6-929b-b2f2e19b28fc" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_aa94a20a-ee6a-444e-8acb-7c21b2928924" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_fa326332-3a66-49a1-be48-2f781986d314" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_c5314333-f436-4ad6-929b-b2f2e19b28fc" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_fa326332-3a66-49a1-be48-2f781986d314" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_215ee70c-ff52-41ae-bae8-6fe1131c6b63" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_dec69fbe-b16f-4463-8f6b-724c4657ffd4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_215ee70c-ff52-41ae-bae8-6fe1131c6b63" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_dec69fbe-b16f-4463-8f6b-724c4657ffd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_ad1e4ca6-0887-445a-afc5-3ebba4e867e4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_215ee70c-ff52-41ae-bae8-6fe1131c6b63" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_ad1e4ca6-0887-445a-afc5-3ebba4e867e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_8d19a6a5-6e34-4da8-b083-ac88bdd3ac51" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_215ee70c-ff52-41ae-bae8-6fe1131c6b63" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_8d19a6a5-6e34-4da8-b083-ac88bdd3ac51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_300cd75d-d95a-4bc6-b68f-bef2aa327896" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_25ee12d9-7102-4f8b-93e0-7cc938379414" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_300cd75d-d95a-4bc6-b68f-bef2aa327896" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_25ee12d9-7102-4f8b-93e0-7cc938379414" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_506bfa59-77a6-4a74-b6dc-e3b9389d295e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_300cd75d-d95a-4bc6-b68f-bef2aa327896" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_506bfa59-77a6-4a74-b6dc-e3b9389d295e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_6193aea9-5554-4ad6-80a2-fb4c9c034c6f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_300cd75d-d95a-4bc6-b68f-bef2aa327896" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_6193aea9-5554-4ad6-80a2-fb4c9c034c6f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfIncomeTaxDifferenceFromStatutoryRateDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesScheduleOfIncomeTaxDifferenceFromStatutoryRateDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfIncomeTaxDifferenceFromStatutoryRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_fc6c6682-ac86-4a44-981b-ce8795df078c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_fc6c6682-ac86-4a44-981b-ce8795df078c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_e27fee0e-7ab1-4cea-942f-ef9658bf72bf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_e27fee0e-7ab1-4cea-942f-ef9658bf72bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_275a688c-6976-4a69-a937-2452bf48d134" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_275a688c-6976-4a69-a937-2452bf48d134" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_EffectiveIncomeTaxRateReconciliationForeignTaxReformAmount_f640b0f2-fb2d-486c-8c28-64f590b6fba8" xlink:href="isrg-20201231.xsd#isrg_EffectiveIncomeTaxRateReconciliationForeignTaxReformAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_isrg_EffectiveIncomeTaxRateReconciliationForeignTaxReformAmount_f640b0f2-fb2d-486c-8c28-64f590b6fba8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_8cbb328b-1c52-48ac-bf1a-ec5022459f24" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_8cbb328b-1c52-48ac-bf1a-ec5022459f24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationDeductionsQualifiedProductionActivities_f47cc15f-f00a-4cc2-b759-52e5b08bbf52" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationDeductionsQualifiedProductionActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationDeductionsQualifiedProductionActivities_f47cc15f-f00a-4cc2-b759-52e5b08bbf52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_3eab7188-21aa-4c0e-97db-1a690b974413" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_3eab7188-21aa-4c0e-97db-1a690b974413" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_97efe61f-e721-43e4-a277-5352a08df210" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_97efe61f-e721-43e4-a277-5352a08df210" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_IncomeTaxReconciliationUnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations_8ecf2670-60d2-4254-b40b-a24efc5a80f7" xlink:href="isrg-20201231.xsd#isrg_IncomeTaxReconciliationUnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_isrg_IncomeTaxReconciliationUnrecognizedTaxBenefitsReductionsResultingFromLapseOfApplicableStatuteOfLimitations_8ecf2670-60d2-4254-b40b-a24efc5a80f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationRepatriationOfForeignEarnings_9f1eda37-a066-422c-82df-5c8d7397bbd8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationRepatriationOfForeignEarnings"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationRepatriationOfForeignEarnings_9f1eda37-a066-422c-82df-5c8d7397bbd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_66babb47-ec44-44d6-8cc3-b02c4b32d744" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_66babb47-ec44-44d6-8cc3-b02c4b32d744" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_90da89b4-a769-4a00-bd01-e96c27694b2b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_ea5c6c88-106b-484d-9652-338f3f80f574" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_90da89b4-a769-4a00-bd01-e96c27694b2b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesScheduleOfDeferredTaxAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_a9e7dff2-b44c-431a-b250-62f1288ae2d8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_DeferredTaxLiabilitiesRightOfUseAsset_969c8157-d492-429b-8a3b-482ed4ac76cb" xlink:href="isrg-20201231.xsd#isrg_DeferredTaxLiabilitiesRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a9e7dff2-b44c-431a-b250-62f1288ae2d8" xlink:to="loc_isrg_DeferredTaxLiabilitiesRightOfUseAsset_969c8157-d492-429b-8a3b-482ed4ac76cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_cf45c0fc-7f36-485e-9b79-da46e94e33c5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a9e7dff2-b44c-431a-b250-62f1288ae2d8" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_cf45c0fc-7f36-485e-9b79-da46e94e33c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_86b2a382-4488-4894-9948-7c57716635c4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a9e7dff2-b44c-431a-b250-62f1288ae2d8" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_86b2a382-4488-4894-9948-7c57716635c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_64490388-d4a7-4714-b082-f5eee72a6a67" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_a9e7dff2-b44c-431a-b250-62f1288ae2d8" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_64490388-d4a7-4714-b082-f5eee72a6a67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_dd6eb8cd-e207-41ab-a36c-3b436dc3a982" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_231d3c0b-60a5-41ef-847d-596ed30bc239" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_dd6eb8cd-e207-41ab-a36c-3b436dc3a982" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_231d3c0b-60a5-41ef-847d-596ed30bc239" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_c640a532-e6f6-4bd1-a593-a2d91f428ff9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_dd6eb8cd-e207-41ab-a36c-3b436dc3a982" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_c640a532-e6f6-4bd1-a593-a2d91f428ff9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_e13620dd-44f2-46b4-869c-db8e18cdd885" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_e13620dd-44f2-46b4-869c-db8e18cdd885" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsOther_228f6c1f-2704-4048-8db5-5a54b501bb4c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsOther_228f6c1f-2704-4048-8db5-5a54b501bb4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_DeferredTaxAssetsOperatingLeaseLiability_cbaec6e9-0efd-4dfc-8341-b00fbb34d441" xlink:href="isrg-20201231.xsd#isrg_DeferredTaxAssetsOperatingLeaseLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_isrg_DeferredTaxAssetsOperatingLeaseLiability_cbaec6e9-0efd-4dfc-8341-b00fbb34d441" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_14a44dfd-a18e-4cb6-af64-6c1295f035e4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_14a44dfd-a18e-4cb6-af64-6c1295f035e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_e1a30fcf-a6f4-4119-8464-ede332356079" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_e1a30fcf-a6f4-4119-8464-ede332356079" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_ffc39bf3-6339-4e89-9a11-b3453c5ea5d3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_ffc39bf3-6339-4e89-9a11-b3453c5ea5d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_c2398824-ef4c-46b8-a4b6-c71762d5dd69" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_feda3b61-9190-49cc-828d-6b89ea2409cf" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_c2398824-ef4c-46b8-a4b6-c71762d5dd69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_70a125f1-1f05-4533-813b-ea1fbc1bd601" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_a7de09e3-d374-47d7-abae-4149eb7f8a1d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_70a125f1-1f05-4533-813b-ea1fbc1bd601" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_a7de09e3-d374-47d7-abae-4149eb7f8a1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_9440ffaf-a0c6-4175-922f-7b9a2c29747b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_70a125f1-1f05-4533-813b-ea1fbc1bd601" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_9440ffaf-a0c6-4175-922f-7b9a2c29747b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfGrossUnrecognizedIncomeTaxBenefitsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#IncomeTaxesScheduleOfGrossUnrecognizedIncomeTaxBenefitsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IncomeTaxesScheduleOfGrossUnrecognizedIncomeTaxBenefitsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NetIncomePerShare" xlink:type="simple" xlink:href="isrg-20201231.xsd#NetIncomePerShare"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NetIncomePerShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NetIncomePerShareTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#NetIncomePerShareTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NetIncomePerShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NetIncomePerShareComputationOfBasicAndDilutedNetIncomePerShareDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#NetIncomePerShareComputationOfBasicAndDilutedNetIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NetIncomePerShareComputationOfBasicAndDilutedNetIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ae8ac97b-1a04-492b-8534-e23a7e68ff03" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_97acc6bd-a3ca-440a-94b4-854c9f609d71" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ae8ac97b-1a04-492b-8534-e23a7e68ff03" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_97acc6bd-a3ca-440a-94b4-854c9f609d71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_f0571113-4e0e-476c-a455-f57e3a4aadb0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ae8ac97b-1a04-492b-8534-e23a7e68ff03" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_f0571113-4e0e-476c-a455-f57e3a4aadb0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NetIncomePerShareAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#NetIncomePerShareAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NetIncomePerShareAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/EmployeeBenefitPlans" xlink:type="simple" xlink:href="isrg-20201231.xsd#EmployeeBenefitPlans"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/EmployeeBenefitPlans" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/EmployeeBenefitPlansAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#EmployeeBenefitPlansAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/EmployeeBenefitPlansAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SelectedQuarterlyData" xlink:type="simple" xlink:href="isrg-20201231.xsd#SelectedQuarterlyData"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SelectedQuarterlyData" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SelectedQuarterlyDataTables" xlink:type="simple" xlink:href="isrg-20201231.xsd#SelectedQuarterlyDataTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SelectedQuarterlyDataTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SelectedQuarterlyDataScheduleOfSelectedQuarterlyDataDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#SelectedQuarterlyDataScheduleOfSelectedQuarterlyDataDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SelectedQuarterlyDataScheduleOfSelectedQuarterlyDataDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ValuationAndQualifyingAccounts" xlink:type="simple" xlink:href="isrg-20201231.xsd#ValuationAndQualifyingAccounts"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ValuationAndQualifyingAccounts" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/ValuationAndQualifyingAccountsDetails" xlink:type="simple" xlink:href="isrg-20201231.xsd#ValuationAndQualifyingAccountsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/ValuationAndQualifyingAccountsDetails" xlink:type="extended"/>
</link:linkbase>
