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  <xs:element id="isrg_A2010IncentiveAwardPlanMember" abstract="true" name="A2010IncentiveAwardPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_A2010IncentiveAwardPlanAmendmentMember" abstract="true" name="A2010IncentiveAwardPlanAmendmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_PerformanceShareUnitsPSUsMember" abstract="true" name="PerformanceShareUnitsPSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_ShareBasedCompensationArrangementByShareBasedPaymentAwardActualUnitsEarnedPercentageOfTargetUnits" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardActualUnitsEarnedPercentageOfTargetUnits" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="isrg_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceChange" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceChange" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="isrg_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceChangeWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceChangeWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="isrg_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageExercisePriceAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="isrg_ConsolidatingReportingAxis" abstract="true" name="ConsolidatingReportingAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="isrg_ConsolidatingReportingDomain" abstract="true" name="ConsolidatingReportingDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_CostOfSalesProductMember" abstract="true" name="CostOfSalesProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_CostOfSalesServiceMember" abstract="true" name="CostOfSalesServiceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_CostOfSalesProductsAxis" abstract="true" name="CostOfSalesProductsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="isrg_CostOfSalesProductsDomain" abstract="true" name="CostOfSalesProductsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_CapitalizedIntoInventoryMember" abstract="true" name="CapitalizedIntoInventoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_EarningsPerShareAttributableToParentAbstract" abstract="true" name="EarningsPerShareAttributableToParentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="isrg_TotalRevenueMember" abstract="true" name="TotalRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_LongLivedAssetsMaintainedInTheUnitedStatesPercent" abstract="false" name="LongLivedAssetsMaintainedInTheUnitedStatesPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="isrg_AmyL.LaddM.D.Member" abstract="true" name="AmyL.LaddM.D.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_KeithR.LeonardJr.Member" abstract="true" name="KeithR.LeonardJr.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_JamiDoverNachtsheimMember" abstract="true" name="JamiDoverNachtsheimMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_GaryH.LoebMember" abstract="true" name="GaryH.LoebMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_AmalM.JohnsonMember" abstract="true" name="AmalM.JohnsonMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_CraigH.BarrattPhD.Member" abstract="true" name="CraigH.BarrattPhD.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_DavidJ.RosaMember" abstract="true" name="DavidJ.RosaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_JamieE.SamathMember" abstract="true" name="JamieE.SamathMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_JamieE.SamathRuleTradingArrangementCommonStockMember" abstract="true" name="JamieE.SamathRuleTradingArrangementCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="isrg_JamieE.SamathRuleTradingArrangementStockOptionMember" abstract="true" name="JamieE.SamathRuleTradingArrangementStockOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
